By ARPAN SAHOO, JONATHAN SHEN, DARREL D’SOUZA, JOHN REZK, Morganville, USA
Parkinson’s disease is a neurological disorder that affects movement (Mayo Clinic Staff, 2015). Current solutions include surgical therapy or medications, but these solutions are not fully effective. Our solution treats Parkinson’s at its source. Lewy bodies are clumps of alpha-synuclein common to Parkinson’s. Lewy bodies have been shown to cause neurons to die, impairing the nervous system ("Alpha-Synuclein and Parkinson's Disease"). Our solution uses the enzyme NEDD4, which degrades alpha-synuclein, in order to degrade the build-up and allow for recovery. To deliver NEDD4 to the alpha-synuclein, it will be attached to aptamers. Aptamers are RNA nanostructures that bind to specific targets by forming hydrogen bonds. The aptamer will be modified by adding polyethylene glycol (a high density polymer) so that the aptamer will not be affected by nuclease degradation and kidney filtration. By injecting a modified aptamer carrying NEDD4, alpha-synuclein will be destroyed, leading to an effective treatment of Parkinson’s.
By IMANI BECKETT, Los Angeles, California, the USA
Okun’s Law is an empirically observed relationship between changes in unemployment and changes in national output. This experiment used quarterly unemployment, GNP, and GDP data between 2000-2016 to find if Okun's Law held in the 21st century. Since studies supported the theory that the relationship held up in recent times, the hypothesis was that Okun’s Law would hold in the 21st century. A regression analysis was done on the data to see how much it fit with the equation y=1-0.4x, where y is the change in the unemployment rate and x is the change in output. Overall, the data did not fit into the equation when GNP or GDP was the output, from there I concluded that Okun's Law did not hold in the 21st century.
Read more here: https://drive.google.com/file/d/0B6fYIQxjoVuTaTFFTmdFM0tRdE0/view?usp=sharing
Works cited: https://drive.google.com/open?id=0B6fYIQxjoVuTWDVyTmswbGVjd1E
Proving the Existence of Infinitely Many Quadruplets of Points that Form a Parallelogram on Every Smooth, Simple, Plane Curve
By DRIPTO BISWAS, Kolkata, India
In this article, I attempt a semi rigorous proof of a particular property of simple, closed, smooth plane curves. We consider a closed, simple, plane curve C(x,y) ε R^2, which is smooth and well-behaved. We shall prove that there exists infinitely many quadruplets (A,B,C,D) of points A,B,C,D which form a parallelogram. We shall also prove a claim, which shall show that these infinitely many parallelograms are found in infinitely many orientations as well.
By AHIT KAAN TARHAN, Istanbul, Turkey
Mentor: James Butterworth
Cleaning Soiled Hands: Will Alcohol based sanitizers rub soap away? A randomized blind trial on elementary school students
By SPANDAN SENGUPTA, Kolkata, India
ACKNOWLEDGMENTS: Mrs. Manjuli Mukherjee, Class teacher & Biology teacher at St James’ School; Ms. Amrita Nandy, Asst. Manager in Quality Assurance Dept., Apollo Gleneagles Hospitals, Kolkata; Ms. Shilpi Aurora Kundu, Regional Manager, Schülke India Ltd
By THEODORE BAAS, Michigan, the USA
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